Vaccines Scientific Leaders Program 2022 Belgium: Development of advanced 3D models of lymphoid systems to characterize vaccine immunity

This is an exciting opportunity for a brilliant PhD level scientist to join a world leading Vaccines Research & Development environment. You?ll be channeling your passion for science and helping to revolutionize the future of Vaccines R&D at GSK whilst fostering strong foundations for a career in cutting edge science. Do you want to be part of a company investing in scientific and technical excellence to develop a pipeline of new products to meet the needs of patients across world? Please read on for more details on this unique opportunity and details on how to apply. About Vaccine R&DAs vaccine development has advanced, new types of vaccines have arisen, presenting challenges in characterization and further linking characteristics to function. However, recent development of vaccines against current pandemics or more complex diseases such as has met difficulties. In addition, the gaps in our knowledge on protective responses against pathogens are a significant barrier to ideal vaccine design and are often associated with increased risk of clinical failure.What is Vaccines Scientific Leaders Programme?The Scientific Leaders Programme in Vaccines is a 2-year global programme which builds a pipeline of scientists with the right expertise, technical capabilities and behaviours to drive the future in Vaccines Research and Development. How does the Vaccines Scientific leaders Programme work? You will spend two years working on a key development project, contributing to key strategic areas of our Vaccines R&D business. We have three location options; Italy, Belgium or US which aligns to our Vaccine R&D hubs. Working on challenging projects will provide you with in-depth knowledge of the ways in which Science and Technology is being applied across R&D in GSK. All associates will be contributing to our mission to improve the quality of human life, by enabling people to do more, feel better and live longer ? all while fostering strong foundations for a future career in science.Is the Vaccines Scientific leaders Programme for you? This is a scientific/technical leadership position where you will be empowered to be innovative, collaborative, decisive and bold to solve novel R&D problems. On completion of the 2-year programme we aim to bring you on-board into available technical leadership roles that best suits business? needs and your abilities.We need Scientific leaders to help embed modern Scientific principles and ways of working within the vaccines R&D organisation. You will do this through:Project Title: Development of advanced 3D models of lymphoid systems to characterize vaccine immunityProject proposal:GSK Research & Development is a pioneer in the field of developing innovative vaccines, based on existing or emerging technologies such as adjuvants or RNA vectors. Advanced 3D in vitro models are the cornerstone for translating basic research into clinical success, aligned with our ethical commitment to limit and eventually replace animal use. GSK R&D is largely investing in developing and implementing micro-physiological 3D in vitro models for screening, characterizing and comparing vaccine candidates for better predicting their real-life efficacy.Responsibilities:Within the Adjuvant Research & Systems Vaccinology preclinical group and in partnership with matrix teams that drive our adjuvant and clinical translation vaccine strategies, you will in house design, implement and master advanced in vitro immune organoid models, i.e. equivalent 3D human lymphoid compartment composed of key innate and adaptive cells, that will enable: screening of innovative adjuvant formulations or alternatives to existing immunoenhancers characterizing RNA vaccines and associated formulations including analysis of innate responses, reactogenicity-related biomarkers, and quality of adaptive immunity.deciphering and comparing mechanisms of action of vaccine technologies (e.g. adjuvant, RNA vectors, others) for better informing prophylactic or therapeutic medicine development.This is a groundbreaking position in the GSK Vx organization by specifically driving our internal program with the ambition of stirring away from animal models with limited predictivity towards in vitro lymphoid systems for bringing more and better vaccine candidates to clinical success. In this position, you will also network with internal and external key opinion leaders for scouting and assessing advanced in vitro 3D models. The every day job will consist in being exposed to strategic discussions, turn project needs into actual solutions, perform wet-lab activities, analyze data, run the biological interpretation, and communicate it to scientific leaders. You will also be responsible for scientifically contributing to ongoing collaboration(s) in this field of expertise within GSK or with 3rd parties, and initiate novel partnerships if necessary. To be successful in this role you should have:PhD in immunology or equivalent Proven experience in organoid biology / 3D in vitro modelsHands on experience in the development and implementation of validated or exploratory advanced in vitro co-culture systems Strong expertise in data analysis and interpretation Experience in microscale immunological and biological read-outs tailored to micro-physiological in vitro models would be advantageousThe ability to deal with complexity. Have strong problem-solving and self-directional abilities.Excellent interpersonal skills Excellent written and oral communication skills. Ability to convey scientific messages across multidisciplinary functions.Good planning, prioritization and organisational skillsEnglish is mandatory. Knowledge of French is a plusAvailable Location: Belgium ? RixensartWe recommend you apply as soon as possible, because we accept ongoing applications and will close this vacancy once we have enough applications. #SLP *LI-GSKIf you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements.Our goal is to be one of the world?s most innovative, best performing and trusted healthcare companies. We believe that we all bring something unique to GSK and when we combine our knowledge, experiences and styles together, the impact is incredible. Come join our adventure at GSK where you will be inspired to do your best work for our patients and consumers. A place where you can be you, feel good and keep growing.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.

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